University of Minnesota
College of Food, Agricultural and Natural Resource Sciences
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Minnesota Obesity Center

1999 Grant Awards

Is Resistance Training Protective Against Age Associated Increases in Body Weight?

M. Kathryn H. Schmitz, Ph.D., M.P.H.
Division of Epidmiology
University of Minnesota

There has been limited research on the efficacy of interventions to prevent weight gain. This pilot study focuses on increased physical activity, specifically weight training, to increase energy expenditure for the purpose of preventing weight gain. Evidence that physical activity may be protective against weight gain includes cross-sectional data showing lower weight in physically active than sedentary free-living adults. In this study, it is predicted that in normal and moderately overweight middle-aged pre-menopausal women, 15 weeks of progressive resistance weight training followed by maintenance of muscle mass increases over 6 months through a muscle mass maintenance weight training program (a total of 9 months of resistance training) will prevent increases in body fat % and body weight when compared to no-treatment controls.

The feasibility of maintaining lean body mass increases from progressive resistance weight training through a 6 month muscle mass maintenance weight training program will be established. It will be determined whether 9 months of resistance training (15 weeks progressive resistance weight training followed by 6 months muscle mass maintenance weight training) will prevent body fat % and weight increases in treatment compared to control group participants. In addition, the effect of progressive resistance weight training plus a 6 month muscle mass maintenance weight training program on fasting blood insulin and glucose levels, as well as fasting triglycerides and low and high density lipoprotein cholesterol will be examined.


Identification and Characterization of Genes/Proteins Expressed During Obesity Coupled Insulin Resistance in AP2(-/-) Mice.

Bruce A. Witthuhn, Ph.D.
Department of Biochemistry, Molecular Biology and Biophysics
University of Minnesota

Obesity is characterized by an increase in free fatty acids, triglycerides and a propensity to develop insulin resistance and diabetes. The ability of an individual to maintain normal energy homeostasis is dependent on the response to dietary glucose and fats. Mice which lack the gene for adipocyte fatty acid binding protein, aP2 -/-, have been shown to develop dietary obesity, similar to their wild type mates on a high fat diet, but failed to develop insulin resistance, diabetes or an increase in serum glucose levels characteristic of wild type individuals on a similar diet. The protection from dietary induced insulin resistance that mice lacking aP2 expression extol provides a model system of study.

This study will:

  1. assess the hypothesis that protection from dietary induced insulin resistance is characterized by the altered expression of proteins in animals that are deficient in aP2;

  2. identify and characterize these proteins for their role in dietary induced insulin resistance proteins; and

  3. assess the hypothesis that dietary induced insulin resistance in wild type and not in aP2 -/- mice alters proximal signaling events of the insulin receptor.

Recipients of:

2010 Grant Awards
2008 Grant Awards
2006 Grant Awards
2004 Grant Awards
2003 Grant Awards
2002 Grant Awards
2001 Grant Awards
2000 Grant Awards
1999 Grant Awards
1998 Grant Awards
1997 Grant Awards
1996 Grant Awards
1995 Grant Awards


Call for Proposals

Pilot & Feasibility Program Grant Awards

Advancements in Obesity Research

Other Pilot & Feasibility Program Projects

Pilot & Feasibility Program Supplements