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College of Food, Agricultural and Natural Resource Sciences
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Minnesota Obesity Center

2008 Grant Award - Aaron S. Kelly, Ph.D.

GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children: A Randomized, Controlled Pilot Study

Aaron S. Kelly, Ph.D.
Department of Pediatrics, University of Minnesota

Behavioral therapy should be the foundational approach to treating obesity and impaired glucose tolerance (IGT) in children. However, many children are unable to alter their lifestyle sufficiently and may benefit from medical therapy to facilitate weight loss and improve glucose metabolism. Few drug therapies for weight loss exist for children and novel options should be explored. Exenatide is a new glucagon like peptide-1 (GLP-1) agonist that reduces postprandial glucose excursions and reduces body weight through its ability to slow gastric emptying and by suppressing appetite. Importantly, the weight loss effects with exenatide are progressive and sustained over a period of at least 2 years. Our primary aim is to examine the effects of 6 months of exenatide treatment on body weight, body mass index (BMI), waist circumference, body composition, and glucose tolerance in obese children with IGT. Our secondary aim is to examine the effects of exenatide treatment on arterial endothelial function and stiffness, blood biomarkers of endothelial activation, and adipokines in obese children with IGT. To accomplish these aims, we will enroll 20 obese children and adolescents into a randomized, single-blind, controlled clinical trial. Patients will be randomly assigned to exenatide (n = 10) or usual care (n = 10) for 6 months in addition to background behavioral therapy through the UMN Pediatric Weight Management Program. This multidisciplinary pilot study will result in the acquisition of valuable preliminary data which will be used to seek funding for and conduct a larger-scale clinical trial evaluating the safety and efficacy of GLP-1 therapy for weight loss and improved glucose tolerance in obese children with IGT.

2008 Awards:

GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children: A Randomized, Controlled Pilot Study

Regional Free Fatty Acid Uptake Assessed by Positron Emission Tomography in Humans: A Pilot and Feasibility Study

Role of Skeletal Hormones in Adipocyte Differentiation and Function

Bone and Cardiovascular Health in Obese Adolescents Following Bariatric Surgery

Recipients of:

2010 Grant Awards
2008 Grant Awards
2006 Grant Awards
2004 Grant Awards
2003 Grant Awards
2002 Grant Awards
2001 Grant Awards
2000 Grant Awards
1999 Grant Awards
1998 Grant Awards
1997 Grant Awards
1996 Grant Awards
1995 Grant Awards