Adipose Biology, Obesity and Energy Metabolism
Research Focus: The adipose cell research group explores the molecular and cellular biology of adipose tissue, with particular interests in adipose metabolism and its role in the development of obesity and insulin resistance. Studies carried out by faculty in this focal group emphasize the development of adipose tissue, transcriptional control of adipocyte genes, the role of adipose inflammation in metabolic disease and the linkage between adipose biology of overall energy homeostasis. This focal group extends beyond fat biology to include work in muscle and liver (Chini, Jensen and Mashek) that integrates with obesity. Moreover, model systems such as flies and worms are studied (O’Connor) to utilize genetics as a major experimental tool.